The biorevolution has given us the ability to genetically reprogram microbes for a range of exciting applications, from miniscule chemical factories to biological computers that can sense their chemical environment and implement complex decision-making algorithms. The overall goal of the Woolston lab is to harness this potential to provide solutions to the most pressing challenges of the 21st century. We are currently focused on new approaches to sustainably produce the chemicals, fuels and materials we need for our modern lifestyle, and to positively impact health through manipulation of the gut microbiota.
As metabolic engineers, we use a highly interdisciplinary approach combining the latest advances in synthetic biology, a deep understanding of biochemistry, and an engineering mindset to tackle a range of fundamental and applied projects. Our lab is particularly fascinated by non-model microorganisms and poorly studied metabolic pathways, given the potential for exciting scientific discoveries along the way.
As an academic lab, a major part of our mission is to prepare students for a range of exciting careers. Projects in the lab vary, but all students that join the Woolston lab learn state-of-the-art molecular biology techniques, modern analytical instrumentation (HPLC, LC-MS, GC), anaerobic microbiology, bioreactor design and operation, and protein purification & characterization. Beyond wet-lab techniques, trainees learn to apply an engineering mindset to solving biological problems, as well as a range of computational tools ranging from ODE solvers to bioinformatics software. These skills prepare them well for diverse roles in the biotechnology sector.
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